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Joined 1 year ago
Cake day: November 15th, 2023
  • Atelopus-zeteki@kbin.runtoVideos@lemmy.world•Project 2025 Explained
    15·
    7 months ago

    https://en.wikipedia.org/wiki/Project_2025

    Executive Summary: Project 2025 envisions widespread changes across the government, particularly economic and social policies and the role of the federal government and its agencies. The plan proposes taking partisan control of the Department of Justice (DOJ), the Federal Bureau of Investigation (FBI), the Department of Commerce, the Federal Communications Commission (FCC) and Federal Trade Commission (FTC), dismantling the Department of Homeland Security (DHS), and sharply reducing environmental and climate change regulations to favor fossil fuel production.[7][12] The blueprint seeks to institute tax cuts,[13] though its writers disagree on the wisdom of protectionism.[14] Project 2025 recommends abolishing the Department of Education, whose programs would be either transferred to other agencies, or terminated.[15][16] Funding for climate research would be cut while the National Institutes of Health (NIH) would be reformed along conservative principles.[17][18] The Project urges government to explicitly reject abortion as health care[19][20] and eliminate coverage of emergency contraception under the Affordable Care Act.[21] The Project seeks to infuse the government with elements of Christianity.[6] It proposes criminalizing pornography,[22] removing legal protections against discrimination based on sexual orientation and gender identity,[22][23] and terminating diversity, equity, and inclusion (DEI) programs,[3][23] as well as affirmative action.[24] Some conservatives and Republicans have criticized the plan for its stance on climate change[25] and foreign trade.[14] Other critics believe Project 2025 is rhetorical “window-dressing” for what would be four years of personal vengeance at any cost.[26] The project’s authors also acknowledged that most of the proposals would require the Republican Party to control both the U.S. House of Representatives and the U.S. Senate.[26] Other aspects of the plan have recently been ruled unconstitutional by the Supreme Court and would face court challenges, while others still are norm-breaking proposals that might survive court challenges.[27]

    The Project recommends the arrest, detention, and deportation of undocumented immigrants living in the United States.[28] It promotes capital punishment and the speedy “finality” of those sentences.[29] Dans acknowledged it was “counterintuitive” to recruit so many to join the government to shrink it, but pointed out the need for a future president to “regain control” of the government.[3] Although the project cannot by law promote a specific presidential candidate, many contributors have close ties to Donald Trump and his 2024 presidential campaign.[30][31] The Washington Post called the project “the most detailed articulation of what a second Trump term would look like.”[32] While initially[when?] the Trump campaign said the project aligned well with their Agenda 47 proposals,[26] the Project has increasingly caused friction with the Trump campaign which has generally avoided specific policy proposals that can be used to criticize him.[32] In July 2024, Trump disavowed Project 2025.[33]

  • Atelopus-zeteki@kbin.runtoscience@lemmy.world•Major cause of inflammatory bowel disease found
    303·
    8 months ago

    From the abstract: "By investigating an intergenic haplotype on chr21q22—which has been independently linked to inflammatory bowel disease, ankylosing spondylitis, primary sclerosing cholangitis and Takayasu’s arteritis3,4,5,6—we identify that the causal gene, ETS2, is a central regulator of human inflammatory macrophages and delineate the shared disease mechanism that amplifies ETS2 expression. "

    I guess you owe me five bucks.

  • Atelopus-zeteki@kbin.runtoscience@lemmy.world•Major cause of inflammatory bowel disease found
    291·
    8 months ago

    It was her all along!

    A disease-associated gene desert directs macrophage inflammation through ETS2 https://www.nature.com/articles/s41586-024-07501-1

    Abstract

    Increasing rates of autoimmune and inflammatory disease present a burgeoning threat to human health1. This is compounded by the limited efficacy of available treatments1 and high failure rates during drug development2, highlighting an urgent need to better understand disease mechanisms. Here we show how functional genomics could address this challenge. By investigating an intergenic haplotype on chr21q22—which has been independently linked to inflammatory bowel disease, ankylosing spondylitis, primary sclerosing cholangitis and Takayasu’s arteritis3,4,5,6—we identify that the causal gene, ETS2, is a central regulator of human inflammatory macrophages and delineate the shared disease mechanism that amplifies ETS2 expression. Genes regulated by ETS2 were prominently expressed in diseased tissues and more enriched for inflammatory bowel disease GWAS hits than most previously described pathways. Overexpressing ETS2 in resting macrophages reproduced the inflammatory state observed in chr21q22-associated diseases, with upregulation of multiple drug targets, including TNF and IL-23. Using a database of cellular signatures7, we identified drugs that might modulate this pathway and validated the potent anti-inflammatory activity of one class of small molecules in vitro and ex vivo. Together, this illustrates the power of functional genomics, applied directly in primary human cells, to identify immune-mediated disease mechanisms and potential therapeutic opportunities.