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Cake day: December 6th, 2023

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  • https://pubmed.ncbi.nlm.nih.gov/?term=alzheimer's+virus

    I’m not the poster you’re contempting, I’m just some asshole Empiricist who works to consistently check before contempting.

    Scientific-integrity is not in the culture I grew-up in ( dad’s medical-culture Scientism has no tolerance for it, neither did mom’s Catholicism ),

    but it is required for outright intellectual-integrity.

    For those who won’t check the link to see the results, here is the abstract from 1 paper:

    Infectious agents and Alzheimer’s disease

    Abstract

    Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Individuals affected by the disease gradually lose their capacity for abstract thinking, understanding, communication and memory. As populations age, declining cognitive abilities will represent an increasing global health concern. While AD was first described over a century ago, its pathogenesis remains to be fully elucidated. It is believed that cognitive decline in AD is caused by a progressive loss of neurons and synapses that lead to reduced neural plasticity. AD is a multifactorial disease affected by genetic and environmental factors. The molecular hallmarks of AD include formation of extracellular β amyloid (Aβ) aggregates, neurofibrillary tangles of hyperphosphorylated tau protein, excessive oxidative damage, an imbalance of biothiols, dysregulated methylation, and a disproportionate inflammatory response. Recent reports have shown that viruses (e.g., Herpes simplex type 1, 2, 6A/B; human cytomegalovirus, Epstein-Barr virus, hepatitis C virus, influenza virus, and severe acute respiratory syndrome coronavirus 2, SARS-CoV-2), bacteria (e.g., Treponema pallidum, Borrelia burgdorferi, Chlamydia pneumoniae, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, Fusobacterium nucleatum, Aggregatibacter actinomycetemcmitans, Eikenella corrodens, Treponema denticola, and Helicobacter pylori), as well as eukaryotic unicellular parasites (e.g., Toxoplasma gondii) may factor into cognitive decline within the context of AD. Microorganisms may trigger pathological changes in the brain that resemble and/or induce accumulation of Aβ peptides and promote tau hyperphosphorylation. Further, the mere presence of infectious agents is suspected to induce both local and systemic inflammatory responses promoting cellular damage and neuronal loss. Here we review the influence of infectious agents on the development of AD to inspire new research in dementia based on these pathogens.

    bold-highlighting is by me.






  • Paragone@lemmy.worldtoscience@lemmy.worldrules discussion
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    4 months ago

    Explicitly mention in the rules, that if someone finds an item on some not-allowed-source interesting,

    then they should go look-for a proper-science article giving the same core-meaning

    & that would be acceptable.

    There’s a principle that the most-famous-convict-in-the-world held-to, that Science is supposed to also hold-to…

    “it doesn’t matter who says it: if it’s True, then it’s True, end-of-story.”

    I’ve seen “authorities” assert that there is “no scientific evidence” or “no valid evidence” for some supplement, then simply gone on PubMed & found 800-ish peer-reviewed articles on exactly that supplement, so the “authorities” are just pushing ideology/prejudice, since evidence has been contradicting them for years, before they made their “authoritative” declaration…

    I’m kinda fed-up with Scientism masquerading & gaslighting as Empiricism, you know?

    ( & this doesn’t even touch the nobody will do the experiment, therefore there’s no “evidence” because nobody “can afford” to assert the evidence bullshit…

    A South Korean experiment, iirc, years ago, did a single-plutonium-atom-in-each-of-some-mice experiment, letting the mice reproduce, & then cracking whether there was any statistically-significant-cancer-rate-difference in the plutonium-adulterated lineages, vs the others…

    & discovered that there is…

    But, of course, if THAT were replicated, then … ALL nuclear-safety-regulations would be trashed, because the multiple-generations-tests are NOT done, because we CAN’T afford to know that!!, right??

    Same with the “we don’t know what could be causing The Cold Blob™ off of Greenland, but we won’t include Greenland ice-melt in our climate-models, so therefore there’s NO SCIENTIFIC EVIDENCE that that’s what it is!!” gaslighting…

    NOW they’ve done that inclusion, & discovered that AMOC began shutting-off around 1950, & this-decade will see about 1,000,000+ fewer cubic km of flow, than the 1940-1950 decade ( Nature Geoscience for that article, it was linked from Earth.com, a few days ago )…

    Won’t-do-the-experiment is itself pseudoscience!!

    Feel free to delete my comment from this discussion, since it contradicts consensus/Scientism’s establishment…

    Here’s the AMOC-is-shutting-down, will be down 33% at 2C, article:

    https://www.nature.com/articles/s41561-024-01568-1

    Here’s The Cold Blob whose source hasn’t been scientifically established, to use their phrase:

    https://en.m.wikipedia.org/wiki/Cold_blob

    ( seriously: what ELSE could be its source??

    Greenland’s nearly-6k-cubic-km in the last few years icemelt HAS to go somewhere, right?

    Isn’t considered-reasoning part of The Scientific Method, anymore?

    )

    _ /\ _


  • Reading the PDF…

    The “most preferred leadership behavior” is … being male?

    Uncertainty-avoidance ( that’s a Hofstede dimension, why do they seem to be claiming otherwise? ) is 2nd, which explains why ideology/prejudice, Kahneman1-mind, for anybody who has read his “Thinking Fast and Slow”, on the 2 mind-systems, is preferred to considered-reasoning!

    Damn…

    Humankind … hasn’t got a chance in hell, … of surviving this century’s challenges,

    has it?

    That kind of polarization/programming … is completely incompatible with species-wide adapting.

    Here are some background links, for you people:

    https://en.m.wikipedia.org/wiki/Hofstede's_cultural_dimensions_theory#Dimensions_of_national_cultures

    https://en.wikipedia.org/wiki/Global_leadership

    I think they really missed a trick, by not looking into whether Kegan4 or Kegan5 is preferred, in leadership, in different cultures ( though Hofstede’s Success-orientation, formerly “masculinity”, would be a reliable indicator for Kegan4 & against Kegan5 )…

    Kegan4’s … bulling-boss mode, it’s a stage-of-unconscious-mind-development which is pushing-out-unacceptable-meaning, & its instinct “knows” that validity is zero-sum: anybody else having any validity, that costs one’s own ( exclusive ) validity.

    Kegan5’s … systems-of-systems mode.

    scroll down a bit, from this link, & read the table…

    https://en.m.wikipedia.org/wiki/Robert_Kegan#The_Evolving_Self

    Kegan & Lahey’s book “Immunity to Change” is on 3, 4, & 5, & how not getting one’s unconscious-mind to change utterly destroys potential, for little reason.

    They provide leverages for getting one’s unconscious to grow-up, too…

    _ /\ _


  • Oh, this need be added:

    Lanier never published in academia, ttbomk, only through her book…

    However, Universe couldn’t possibly care if a meaning is published outside, or inside, of academia’s filter-bubble, crowded as it now is with “paper mills” and their fake-science publications…

    Scientific Method is the ONLY test for Truth of something, right?

    Lanier’s stuff tests-out.

    Contempting it, because a particular filter-bubble hasn’t “authorized” it to be True in Universe’s eyes, is … cultural chauvanism, & nothing else…

    Universe isn’t, in any way whatsoever, dependent on academic-filter-bubble for What It Holds To Be True, right?

    I’ve a test of her Tropical culture vs Nordic culture that for me hammers-it-home:

    I’ve spent years as a homeless person, including out in the bush.

    WHEN failure to do something oneself WILL terminate one’s life in the cold, THEN one gets off one’s ass & doesn’t rely on “society” to “take care of one”, right?

    That isn’t in Tropical culture, only in cultures where cold threatens individual-survival/viability.

    People can debate all they want about whether it’s significant, or not, or valid, or not,

    but … go out there & put your life on the line for a few winters & see if it alters your instincts, or not, eh?

    I say it does, & that no amount of ideological bullshit can falsify the evidence that direct-experiment produced, in altering me.

    People who won’t do the experiment say “it isn’t proven”, & they won’t accept the testimony of people who have done the experiment…

    Hence my inability to respect ivory-tower “authority” which won’t do the experiment, rejects evidence contradicting its filter-bubble, etc…

    Do the experiment , that is rule number ZERO, right?

    Empiricism!

    Lanier’s stuff checks-out, through & through, & its not having been published within academia’s filter-bubble in no way, whatsoever, negates its validity.

    _ /\ _


  • This seems spot-on.

    I do wish, however, that it wasn’t only Hofstede’s research that was being used as a reference, as Lanier’s “Foreign to Familiar” is, while identifying fewer dimensions, every bit as fundamental as Hofstede’s “Exploring Culture” book is…

    Lanier identifies the Tropical vs Nordic cultural dimension, & also the old-culture vs new-culture dimension,

    neither of which Hofstede seems to have acknowledged.

    Lanier isn’t male, of course, so expecting male-academia to do anything other than ignore her work … isn’t going to accomplish anything, this century, is it?

    & as for the people who automatically-contempt automatic-machine-learning, it’s a brilliant use of technology:

    let the machine identify what the factors are, & which way they’re going, in the different cultures.

    Think of it as enhanced data-mining, & that’s the best idea to know it as, really…

    Not even slightly related to the generative-LLMs with their hallucinations, at all.

    This article is a treasure: to the one who posted this, https://lemmy.world/u/Joker@sh.itjust.works , Thank You!

    _ /\ _




  • Remember that “journalist” who admitted, in an interview on iirc “Joe Rogan” or something, that CNN+NYT++ systemically “shut down” progressive issues, & progressive voices, in that election…

    I’d been wondering what the hell was wrong, but … propaganda “journalism” won a “battle” I hadn’t even known was being waged…

    Now, of course, the deck is getting stacked,.

    the economic house-of-cards still is being propped-up by China & the US ( different parts of it: the fake-economy of China, & the issue 7x as much currency, but pretend that that doesn’t cause 700% inflation idiocy in the US )… but it must come down.

    IF that economic house-of-cards comes down before the election, then the incumbent is hosed.

    Period.

    It’s a slam dunk election for the outsider, then.

    You’d better pray, successfully, for that economic-collapse not happening, until after the election, then, eh?


    Being the old cynic that I am, I’m expecting the republicans to win, to revert the US to Jim Crow’s “reality”, & to finish the Civil War that they pretended to surrender in, so long ago.

    Gutting NATO, backing Russia, the whole everything that Trump promised…


    I’d be preparing, not praying.

    ( & am, tbh: health’s improving… )

    _ /\ _



  • Retrospectology is right:

    Of the 2 parties in the system,

    The Democrat Party is coasting on its assumed-entitlement to win, instead of doing what factually is required, in order to win,

    and they actually are accommodating giving the Republicans victory.

    Even without the coming economic problems, as the extra-printed-money ( thus devaluing the currency ) continues to cause limited-wages to get weaker & weaker & weaker,

    even without that, the backing-of-Israel’s-genociding has cost them the GenZ & Muslim vote, already.

    They’ve got their heads so far up their ass, that they CANNOT understand that Dictator Trump’s going to have some of them executed.

    Moronic making-believing “strategy” doesn’t cut it.

    IF one is in authority, THEN by G-D one is obliged to wield that authority responsibly, and the Dems are in assumptions-land.

    _ /\ _





  • The amount of power you could pull from a single square metre of solar on the roof wouldn’t increase your range meaningfully.

    What it would do, is that you could possibly keep your starter-battery from going dead-flat if you left your car alone for a 1/2 month, in the summer ( snow would cover it, obviously ), & since bringing a lead-acid battery to dead-flat permanently-damages it, this would prevent costly problems for the car-owners.

    ( this happened to a friend with a Prius: had to replace the battery, and the damned thing was inside the rear wheel-well??? in a little compartment.

    Origami-engineering’s … simultaneously incredible & stupidly-frustrating )

    I’ve held for years that they should be doing it to keep the starter-battery trickle-charging, but … why make the customers have fewer costly/frustrating problems?