There’s a crapload of interesting things in this paper!

I suffer from axial spondyloarthritis which causes severe fatigue chalked up to trouble sleeping and ongoing inflammation usually. Underlying symptoms are treated with biologic TNF and IL-17 inhibitors which coincidentally are the same pathways mentioned here for ME. There’s also a new treatment targeting T-Cells selectively approved in Russia and currently tested in China although it has only a biologic-level effectiveness despite the hype according to local reports. It seems to not work for those without HLA-B27 antigen which appears to similarily divide those suffering from AS into two groups like described here with ME.

It sounds like guys with ME have a chance at an effective treatment fairly soon. Cautious yay?

People 18-39 vote predominantly for Konfederacja (far right), KO (populist centre-right), PiS (populist right). I could dig some more precise sources with gender data but I think it’s telling that these are the results even with women in the mix. Coincidentally even among young women voting for far right is more common than for centre-left. I’m not mentioning left since their popularity is within a margin of error.

Yeah, artists skew left but you won’t find a more bigoted libertarian than a young polish programmer. Most of them are also pretty spoiled too because of the degressive tax system that favours them so much.

Please stop blaming those things on everything except people. I’m Polish. Polish people drink homophobia with their mothers milk. We didn’t need to import it from US or Russia (it’s still better than in the 90s). Average developer is a young male who predominantly votes for outright fascists. The reason CDPR appears progressive is because they calculated it to be more profitable.

Same but both seem to be quite inspired by old Desktop Dungeons so I’m interested anyway.

Cancer seems to be less of an issue with biologic DMARDs and with NSAIDs there are bigger cardiovascular issues to be worried about. But either way it’s trading bad outcomes.

My observation of online communities for chronic diseases is that there are some people that read new research papers and share new findings because there’s so little else they can do. Knowledge in those communities spreads fast (but so does bullshit unfortunately).

It’s a little bit of good news for folks with autoimmune diseases. I’ve been reading a lot on spondyloarthritis / psoriasis over the last couple of weeks (being tested for both) and this doesn’t appear to be common knowledge.

Apple Arcade is still going and getting plenty of releases. I don’t know anyone buying it specifically but including it in Apple One (competitively priced subscription for most Apple services) means lots of people have access to it. Me and my partner use it a lot. It’s very nice knowing that those games won’t try to shove microtransactions down my throat.

This is not up to Harris or politicians to fix, they are not capable of getting people out of this. They will just let you down in new and innovative ways. You talk about the changes they are doing now but I was talking the changes that they’ll need to get reelected in the future - it will be grim and similar to what’s happening all over Europe. Centrist liberal parties are becoming indistinguishable from parties they lost power to (Labour in UK, Renaissance in France, Civic Platform in Poland). It will discourage even more people from participating in politics.

People need to get out in front before it happens to minimise the damage. This means more respect towards people we don’t agree with and that unfortunately includes less poo slinging at bigots. This also means less involvement in treating symptoms because it depletes our capacity for change („orphan-crushing machine”).

Yeah, that’s what I’m warning you about. This approach has been tried. Whatever happens, it was already decided because you’re not going to course correct at eleventh hour and root cause of general discontent is much deeper than you want to admit.

If you lose you’ll go into democratic resistance, fight every single thing Trump does. By second or third year regular people notice that not much is changing in their lives and then you lose all of your steam. When actual bad stuff happens nobody cares.

Then in a couple of terms people will get tired of the right, vote for the libs and then you realise that those Dems have adopted lots of stuff Republicans did because that was the only way to get back into power. And that it was always about power. I’ll be there to say „told you so”.

I’m trying to explain to Dem voters that their moral high ground and calling everyone a Nazi will lead Republican voters to entrench in views pushed by far right even if they didn’t hold them before. Dem voters are supposed to be the smart ones so they should understand that, right?

In what ways will it be worse / more Nazi than under Nixon? Healthcare? Infrastructure? Minority rights? Black rights? Waging wars and supporting genocide in some third world country? Sorry to break it to you but US was always a borderline fascist state and that includes Democrats.

That feet stomping and refusing to acknowledge reality is a symptom, not the root issue. People don’t feel like they have a real choice so as a response to this overwhelming world they start to treat it like a football match. You support your team no matter what, right?

It’s good that you recognise tribalism as a core issue although you need to acknowledge that you can be victim of that too. You’re trying to start from the top because that looks like it’s have biggest impact but the actual change needs to start at the bottom. This is something we can do but it’ll be much more work than waiting for someone to do that for us. I realise that all of us are so used to slacktivism by now that it sounds like an insurmountable task but there’s no other way. First step is to stop contributing to the problem so here I am trying to explain why current approach won’t work.

So, not much is changing then but you assumed history can only move forward. We’ve reached a point where this belief is pretty much a modern secular religion - nobody guaranteed it would be so. This religion even has prophets like Francis Fukuyama who I blame for popularising it.

It’s likely we will be set back again many times and there’s no guarantee that the end result will be satisfying. The best thing we can do for now is to figure out why those things happen in the first place without attributing blame. The future needs to include everyone, even the bigots. My guess most of the bigots wouldn’t be bigots if they had higher participation in profits that our societies generate. This is because politicians funnel those into the pockets of various oligarchs. Neither Republicans or Dems will fix that unfortunately.

Will US under Trump be more or less of a Nazi state than, for example, under Nixon?

Have you considered being out of touch then?

Most the ones i know that support him are higher class than me.

Statistically this is not a representative group.

Yeah, I was shot by Trump to death twice yesterday. Try to get down go actual issues rather than whatever it is that you’re doing.

I understand what you feel, I was there too accusing others of „symmetrism”. You don’t want to see critique of your side or pointing out that others might not be entirely wrong because you feel like everything you do contributes in some small way to which side will win. But this only leads to dishonesty and overt hyperboles. You’ll be frustrated, anxious and sad when you lose so don’t do that to yourself.

Maybe people voting for Trump don’t care about public healthcare because they don’t trust doctors in general. Maybe they feel that the entire healthcare industry is there to scam them and putting public money would be a waste. They’re probably wrong but you need to consider what led people to vote for someone that promises to dismantle the whole system. Maybe the root cause is something different and that’s what needs addressing first?

For starters, by not assuming every single one of them blames all their problems on people purely based on their birth characteristics. Treat them with no prejudice. You’re likely prejudiced against lower class people and not even realise it. Listen to what they have to say and see what led them to distrust public institutions, what are their troubles and priorities.